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Alpha-1 Antitrypsin (A1AT) is a protein that protects the lungs from any damage by regulating the activity of several enzymes that break down proteins and cause damage to the lung tissue. Some individuals suffer from a deficiency of this enzyme owing to gene mutations and a family history of the deficiency of this enzyme and are at an increased risk of developing a progressive lung disease (emphysema). Newborns and infants with A1AT deficiency suffer from severe liver disease and jaundice. In adults, the deficiency of A1AT increases the risk of severe liver damage, liver cirrhosis and liver cancer. An Alpha-1 antitrypsin test is used to measure A1AT levels in the blood.
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